(3R)-4-(苯基甲基)-3-吗啉羧酸乙酯合成路线 （共 5 条）
反应条件
1: With dimethylsulfide borane complex in tetrahydrofuran T=0 - 20°C; 2: With water in tetrahydrofuran
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/28654 A1, 2007 ;
Location in patent: Page/Page column 65 ;
WO 2007/028654 A1
反应条件
1: 65 percent / pyridine, phenyl dichlorophosphate / 1,2-dimethoxy-ethane / 18 h 2: 60 percent / borane-dimethyl sulphide complex (10 M) / tetrahydrofuran / 18 h View Scheme
参考文献
Brown, George R.; Foubister, Alan J.; Wright, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2577 - 2580
反应条件
1: 1) sodium hydroxide (2 M); 2) sodium borohydride / 1) 30 min; 2) 6-10 deg C 2: 23 percent / sodium hydroxide / H2O / 0 deg C, 30 min, 30-33 deg C, 2 h 3: 65 percent / pyridine, phenyl dichlorophosphate / 1,2-dimethoxy-ethane / 18 h 4: 60 percent / borane-dimethyl sulphide complex (10 M) / tetrahydrofuran / 18 h View Scheme
参考文献
Brown, George R.; Foubister, Alan J.; Wright, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2577 - 2580
反应条件
1: 23 percent / sodium hydroxide / H2O / 0 deg C, 30 min, 30-33 deg C, 2 h 2: 65 percent / pyridine, phenyl dichlorophosphate / 1,2-dimethoxy-ethane / 18 h 3: 60 percent / borane-dimethyl sulphide complex (10 M) / tetrahydrofuran / 18 h View Scheme
参考文献
Brown, George R.; Foubister, Alan J.; Wright, Brian
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2577 - 2580
反应条件
1: With lithium hydroxide; ethanol; water in tetrahydrofuran
T=50°C;
2: With hydrogenchloride in tetrahydrofuran; water
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/28654 A1, 2007 ;
Location in patent: Page/Page column 65-66 ;
WO 2007/028654 A1
