甲基-2-Boc-氨基-4-戊烯酸合成路线 （共 18 条）
反应条件
1: 2-tert-butoxycarbonylaminopent-4-enoic acid With potassium carbonate in DMF (N,N-dimethyl-formamide) 0.25 h; 2: methyl iodide in DMF (N,N-dimethyl-formamide) T=0 - 20°C; 4 h;
参考文献
THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC
Patent: WO2004/99171 A2, 2004 ;
Location in patent: Page 140-141 ;
WO 2004/099171 A2
反应条件
1: D,L-2-amino-4-pentenoic acid; di-tert-butyl dicarbonate With sodium hydroxide in 1,4-dioxane; water T=0°C; 16 h; 2: With hydrogenchloride in 1,4-dioxane; water pH=2; 3: methyl iodide With potassium carbonate more than 3 stages;
参考文献
THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC
Patent: WO2006/55725 A2, 2006 ;
Location in patent: Page/Page column 204-205 ;
WO 2006/055725 A2
反应条件
in methanol; hexane; dichloromethane T=20°C; 3 h;
参考文献
Toray Industries, Inc.
Patent: EP2042171 A1, 2009 ;
Location in patent: Page/Page column 37 ;
反应条件
zinc in N,N-dimethyl-formamide T=20 - 25°C;
参考文献
Abood, Norman A.; Nosal, Roger
Tetrahedron Letters, 1994 , vol. 35, # 22 p. 3669 - 3672
反应条件
cyclohexa-1,4-diene; palladium on activated charcoal in ethanol 1 h; Ambient temperature;
参考文献
Bajwa, Joginder S.
Tetrahedron Letters, 1992 , vol. 33, # 21 p. 2955 - 2956
反应条件
1: thionyl chloride / 12 h / 23 °C 2: 0.62 g / 4-dimethylaminopyridine; NEt3 / acetonitrile / 2 h / 23 °C View Scheme
参考文献
Witulski, Bernhard; Goessmann, Matthias
Chemical Communications, 1999 , # 18 p. 1879 - 1880
反应条件
triethylamine in dichloromethane T=0°C; Acylation;
参考文献
Michaelis, Simon; Blechert, Siegfried
Chemistry - A European Journal, 2007 , vol. 13, # 8 p. 2358 - 2368
反应条件
1: methanol; D,L-2-amino-4-pentenoic acid With thionyl chloride 2: di-tert-butyl dicarbonate With triethylamine in dichloromethane
参考文献
De Matteis, Valeria; Van Delft, Floris L.; Jakobi, Harald; Lindell, Stephen; Tiebes, Joerg; Rutjes, Floris P. J. T.
Journal of Organic Chemistry, 2006 , vol. 71, # 20 p. 7527 - 7532
反应条件
1: Et3N / CH2Cl2 / 20 °C 2: 2.80 g / K2CO3 / acetone / 4 h / Heating View Scheme
参考文献
Allen, Norris E.; Boyd, Donald B.; Campbell, Jack B.; Deeter, Jack B.; Elzey, Thomas K.; et al.
Tetrahedron, 1989 , vol. 45, # 7 p. 1905 - 1928
反应条件
in N,N-dimethyl-formamide 66 h;
参考文献
Biagini, Stefano C. G.; Gibson, Susan E.; Keen, Stephen P.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 16 p. 2485 - 2499
