甲基-2-Boc-氨基-4-戊烯酸合成路线 （共 18 条）
反应条件
1: 75 percent / benzene / Heating 2: 96 percent / pyridine / tetrahydrofuran / Ambient temperature 3: 99 percent / Zn / dimethylformamide / 20 - 25 °C View Scheme
参考文献
Abood, Norman A.; Nosal, Roger
Tetrahedron Letters, 1994 , vol. 35, # 22 p. 3669 - 3672
反应条件
1: 96 percent / pyridine / tetrahydrofuran / Ambient temperature 2: 99 percent / Zn / dimethylformamide / 20 - 25 °C View Scheme
参考文献
Abood, Norman A.; Nosal, Roger
Tetrahedron Letters, 1994 , vol. 35, # 22 p. 3669 - 3672
反应条件
1.1: sodium hydroxide / water; tert-butyl alcohol 1.2: 20 °C 2.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 0 - 20 °C View Scheme
参考文献
Luebke, Martin; Jung, Manfred; Haufe, Guenter
Journal of Fluorine Chemistry, 2013 , vol. 152, p. 144 - 156
参考文献
Sakaitani, Masahiro; Ohfune, Yasufumi
Journal of Organic Chemistry, 1990 , vol. 55, # 3 p. 870 - 876
反应条件
in N,N-dimethyl-formamide 72 h; Ambient temperature; Yield given;
参考文献
Allen, Norris E.; Boyd, Donald B.; Campbell, Jack B.; Deeter, Jack B.; Elzey, Thomas K.; et al.
Tetrahedron, 1989 , vol. 45, # 7 p. 1905 - 1928
反应条件
chiral HPLC in hexane; isopropyl alcohol
Resolution of racemate;
参考文献
Pinto, Andrea; Tamborini, Lucia; Mastronardi, Federica; Ettari, Roberta; Romano, Diego; Nielsen, Birgitte; De Micheli, Carlo; Conti, Paola
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1980 - 1982
反应条件
chiral HPLC in hexane; isopropyl alcohol
Resolution of racemate;
参考文献
Pinto, Andrea; Tamborini, Lucia; Mastronardi, Federica; Ettari, Roberta; Romano, Diego; Nielsen, Birgitte; De Micheli, Carlo; Conti, Paola
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 8 p. 1980 - 1982
反应条件
trifluoroacetic acid in dichloromethane
T=0°C; 0.166667 h;
参考文献
Luebke, Martin; Jung, Manfred; Haufe, Guenter
Journal of Fluorine Chemistry, 2013 , vol. 152, p. 144 - 156
