(1S,9S)-9-(1,3-二氢-1,3-二氧代-2H-异吲哚-2-基)八氢-6,10-二氧代-6H-哒嗪并[1,2-a][1,2]二氮杂卓-1-羧酸叔丁酯合成路线 （共 15 条）
反应条件
thionyl chloride in dichloromethane 4 h; Ambient temperature; Yield given;
参考文献
RANBAXY LABORATORIES LIMITED; KUMAR, Harish; PAREKH, Amar; ARORA, Sanjeev Kumar; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan
Patent: WO2012/49646 A1, 2012 ;
Location in patent: Page/Page column 8 ;
反应条件
1: aq. NaHCO3 2: 97 percent / H2 / Pd/C / methanol 3: PCl5 / tetrahydrofuran 4: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: 97 percent / H2 / Pd/C / methanol 2: PCl5 / tetrahydrofuran 3: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: aq. NaHCO3 2: 97 percent / H2 / Pd/C / methanol 3: PCl5 / tetrahydrofuran 4: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: PCl5 / CH2Cl2 2: aq. NaHCO3 3: 97 percent / H2 / Pd/C / methanol 4: PCl5 / tetrahydrofuran 5: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Attwood, Michael R.; Hassall, Cedric H.; Kroehn, Antonin; Lawton, Geoffrey; Redshaw, Sally
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1986 , p. 1011 - 1020
反应条件
1: 1.) nBuLi / 1.) THF, -78 deg C, 2.) THF 2: 1.) LDA, 2.) Bu4NI, DMPU / 1.) THF, -78 deg C, 2.) CH2Cl2 3: 98 percent / LiOH / tetrahydrofuran; H2O 4: 100 percent / CH2Cl2 5: 98 percent / aq. NaOH / toluene 6: 85 percent / H2SO4 / dioxane 7: aq. NaHCO3 8: 97 percent / H2 / Pd/C / methanol 9: PCl5 / tetrahydrofuran 10: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Chen; Goel; Hyun; Magano; Rubin
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1587 - 1592
反应条件
1: 98 percent / TEA / tetrahydrofuran / Heating 2: PCl5 / CH2Cl2 3: aq. NaHCO3 4: 97 percent / H2 / Pd/C / methanol 5: PCl5 / tetrahydrofuran 6: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Chen; Goel; Hyun; Magano; Rubin
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1587 - 1592
反应条件
1: 98 percent / TEA / tetrahydrofuran / Heating 2: PCl5 / CH2Cl2 3: aq. NaHCO3 4: 97 percent / H2 / Pd/C / methanol 5: PCl5 / tetrahydrofuran 6: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Chen; Goel; Hyun; Magano; Rubin
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1587 - 1592
反应条件
1: 1.) LDA, 2.) Bu4NI, DMPU / 1.) THF, -78 deg C, 2.) CH2Cl2 2: 98 percent / LiOH / tetrahydrofuran; H2O 3: 100 percent / CH2Cl2 4: 98 percent / aq. NaOH / toluene 5: 85 percent / H2SO4 / dioxane 6: aq. NaHCO3 7: 97 percent / H2 / Pd/C / methanol 8: PCl5 / tetrahydrofuran 9: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Chen; Goel; Hyun; Magano; Rubin
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1587 - 1592
反应条件
1: 100 percent / CH2Cl2 2: 98 percent / aq. NaOH / toluene 3: 85 percent / H2SO4 / dioxane 4: aq. NaHCO3 5: 97 percent / H2 / Pd/C / methanol 6: PCl5 / tetrahydrofuran 7: N-ethylmorpholine / tetrahydrofuran View Scheme
参考文献
Chen; Goel; Hyun; Magano; Rubin
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 11 p. 1587 - 1592
