[(2S,3S)-3-(4-溴苯基)环氧乙烷-2-基]甲醇合成路线 （共 3 条）
反应条件
tert.-butylhydroperoxide; Ti(OiPr)4; L-(+)-diisopropyl tartrate in hexane; dichloromethane T=-20°C; Sharpless asymmetric epoxidation; 2.75 h; Molecular sieveInert atmosphere;
参考文献
Jobson, Nicola K.; Spike, Rosemary; Crawford, Andrew R.; Dewar, Deborah; Pimlott, Sally L.; Sutherland, Andrew
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 13 p. 2369 - 2376
反应条件
1: 72 percent / DIBAL-H 2: 74 percent / t-BuOOH; (+)-DIPT / Ti(O-iPr)4 View Scheme
参考文献
Bischoff, Roland; Hamilton, Deborah J.; Jobson, Nicola K.; Sutherland, Andrew
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 323 - 326
反应条件
1: 100 percent / LiCl; DBU 2: 72 percent / DIBAL-H 3: 74 percent / t-BuOOH; (+)-DIPT / Ti(O-iPr)4 View Scheme
参考文献
Bischoff, Roland; Hamilton, Deborah J.; Jobson, Nicola K.; Sutherland, Andrew
Journal of Labelled Compounds and Radiopharmaceuticals, 2007 , vol. 50, # 5-6 p. 323 - 326
