1: With potassium carbonate in tetrahydrofuran; water T=0 - 4°C; 2 h; Industry scale; 2: With sodium hydroxide in tetrahydrofuran; water T=3 - 10°C; pH=13 - 13.5; 4.83333 h; Industry scale; 3: With hydrogenchloride in water T=3 - 6°C; pH=< 2; Industry scale;

1: With potassium tert-butylate in tert-butyl alcohol T=110°C; 3 h; 2: With hydrogenchloride in water pH=1;

1: With sodium hydroxide in water T=0 - 45°C; 4.5 h; 2: With hydrogenchloride in water T=10°C; pH=1;

1: 1) sodium hydroxide (2 M); 2) sodium borohydride / 1) 30 min; 2) 6-10 deg C 2: 23 percent / sodium hydroxide / H2O / 0 deg C, 30 min, 30-33 deg C, 2 h View Scheme

1: 65 percent / pyridine, phenyl dichlorophosphate / 1,2-dimethoxy-ethane / 18 h 2: 60 percent / borane-dimethyl sulphide complex (10 M) / tetrahydrofuran / 18 h View Scheme

1.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 35 - 40 °C / Industry scale 1.2: 40 °C / Industry scale 1.3: 2.25 h / 5 - 15 °C / Industry scale 2.1: hydrogen / 20 palladium(II) hydroxide on carbon / ethanol / 3 h / 20 - 30 °C / 2311.54 Torr / Industry scale View Scheme

dimethylsulfide borane complex; triethylamine in tetrahydrofuran 12 h; Heating / reflux;