1: With 4-(N,N-dimethlyamino)pyridine; benzotriazol-1-ol in DMF (N,N-dimethyl-formamide) T=0°C; 2: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in DMF (N,N-dimethyl-formamide) T=20°C; 18 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/20412 A1, 2004 ;
Location in patent: Page 39 ;
WO 2004/020412 A1