反应条件
1: 3,5-Difluorobenzoic acid With n-butyllithium; N,N,N',N,-tetramethylethylenediamine in 2-methyl tetrahydrofuran; hexane
T=-78 - -65°C; 1.5 h;
2: formic acid methyl ester in 2-methyl tetrahydrofuran; hexane
T=-78 - 20°C; 18.75 h;
3: With hydrogenchloride in water
T=0 - 5°C;
参考文献
ALMIRALL, S.A.; DRACONIS PHARMA, S.L.; LABORATORIOS DEL DR. ESTEVE, S.A.; AGUILAR, Nuria; FERNANDEZ, Joan, Carles; TERRICABRAS, Emma; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi
Patent: WO2013/149997 A1, 2013 ;
Location in patent: Page/Page column 97; 98 ;