反应条件
1.1: sodium hydroxide / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 3 h / Reflux
2.1: 10 palladium on activated charcoal; hydrogen / ethanol
3.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere
View Scheme
参考文献
Brown, Joshua R.; North, Elton J.; Hurdle, Julian G.; Morisseau, Christophe; Scarborough, Jerrod S.; Sun, Dianqing; Kordulakova, Jana; Scherman, Michael S.; Jones, Victoria; Grzegorzewicz, Anna; Crew, Rebecca M.; Jackson, Mary; McNeil, Michael R.; Lee, Richard E.
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5585 - 5595