2-氯-N,N-二甲基乙胺合成路线 （共 199 条）
反应条件
sodium methylate in chlorobenzene
15 h; Heating;
参考文献
Bartl; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 4 p. 1173 - 1186
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate in benzene
T=70 - 80°C; 12 h;
参考文献
Beccalli, Egle M.; Broggini, Gianluigi; Paladino, Giuseppe; Zoni, Caterina
Tetrahedron, 2005 , vol. 61, # 1 p. 61 - 68
参考文献
Leonard; Anderson
Journal of the American Chemical Society, 1955 , vol. 77, p. 4425
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Damiens
Annales de Chimie (Cachan, France), 1951 , vol. <12>6, p. 835,839
参考文献
Christiansen et al.
Acta Chemica Scandinavica (1947-1973), 1953 , vol. 7, p. 128,130
反应条件
sodium methylate in chlorobenzene
参考文献
Bartl; Holubek; Svatek; et al.
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 4 p. 1173 - 1186
反应条件
1: indole With sodium hydride in tetrahydrofuran; mineral oil
T=0°C; 0.5 h;
2: 2-chloro-N,N-dimethylaminoethane in tetrahydrofuran; mineral oil
70 h; Reflux;
参考文献
Hill, Timothy A.; Gordon, Christopher P.; McGeachie, Andrew B.; Venn-Brown, Barbara; Odell, Luke R.; Chau, Ngoc; Quan, Annie; Mariana, Anna; Sakoff, Jennette A.; Chircop, Megan; Robinson, Phillip J.; McCluskey, Adam
Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3762 - 3773
反应条件
sodium hydride
1.) HMPA, RT, 2 h, 2.) HMPA, benzene, RT, overnight; Yield given. Multistep reaction;
参考文献
Glennon; Jacyno; Young; McKenney; Nelson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 41 - 45
反应条件
sodium hydride
1.) HMPA, RT, 2 h, 2.) HMPA, benzene, RT, overnight; Yield given. Multistep reaction;
参考文献
Glennon; Jacyno; Young; McKenney; Nelson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 41 - 45
反应条件
sodium hydride
1.) HMPA, RT, 2 h, 2.) HMPA, benzene, RT, overnight; Yield given. Multistep reaction;
参考文献
Glennon; Jacyno; Young; McKenney; Nelson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 41 - 45
反应条件
sodium hydride
1.) HMPA, RT, 2 h, 2.) HMPA, benzene, RT, overnight; Yield given. Multistep reaction;
参考文献
Glennon; Jacyno; Young; McKenney; Nelson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 41 - 45
