2-氯-N,N-二甲基乙胺合成路线 （共 199 条）
反应条件
sodium hydride
1.) HMPA, RT, 2 h, 2.) HMPA, benzene, RT, overnight; Yield given. Multistep reaction;
参考文献
Glennon; Jacyno; Young; McKenney; Nelson
Journal of Medicinal Chemistry, 1984 , vol. 27, # 1 p. 41 - 45
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=190°C; 1 h; Microwave irradiation;
参考文献
F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BHAGIRATH, Niala; DOMINIQUE, Romyr; KENNEDY-SMITH, Joshua; LOPEZ-TAPIA, Francisco Javier; MERTZ, Eric; QIAO, Qi; SO, Sung-Sau
Patent: WO2014/64131 A2, 2014 ;
Location in patent: Page/Page column 128 ;
参考文献
Iddon, Brian; Price, Donald; Suschitzky, Hans; Scopes, David I.C.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 10 p. 2583 - 2593
反应条件
sodium amide; benzene
参考文献
May; Murphy
Journal of Organic Chemistry, 1955 , vol. 20, p. 257,261
参考文献
Grail et al.
Journal of the American Chemical Society, 1952 , vol. 74, p. 1313
反应条件
sodium ethanolate; sodium amide
1) toluene, reflux, 16 h; 2) EtOH, r.t., 24 h; Yield given. Multistep reaction;
参考文献
Lehmann; Reusch
Archiv der Pharmazie, 1983 , vol. 316, # 11 p. 955 - 960
参考文献
Mattocks; Hutchison
Journal of the American Chemical Society, 1948 , vol. 70, p. 3474
反应条件
sodium ethanolate in ethanol
3 h; Heating;
参考文献
Benedetti, Fabio; Stirling, Charles J.M.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1986 , p. 605 - 612
参考文献
Paquette,L.A.; Rosen,M.
Journal of the American Chemical Society, 1967 , vol. 89, p. 4102 - 4112
参考文献
Tsatsas,G. et al.
Bulletin de la Societe Chimique de France, 1963 , p. 2160 - 2162
