2-氯-N,N-二甲基乙胺合成路线 （共 199 条）
反应条件
potassium carbonate in butanone
T=110°C;
参考文献
Dubey, Sonal; Kaur, Parmeet; Jindal, Dharam Paul; Satyanarayan, Yalamanchili Darji; Piplani, Poonam
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010 , vol. 49, # 7 p. 948 - 955
反应条件
lithium
1.) THF, 2.) THF, 0 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Azzena; Melloni; Fenude; Fina; Marchetti; Sechi
Synthetic Communications, 1994 , vol. 24, # 5 p. 591 - 599
反应条件
in N-methyl-acetamide
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4094870 A1, 1978 ;
反应条件
sodium hydride
1.) mineral oil, DMF, r.t., 20 min; 2.) mineral oil, DMF, r.t., 1 h; Yield given. Multistep reaction;
参考文献
Matsuo; Taniguchi; Ueda
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 4 p. 1141 - 1150
反应条件
in N-methyl-acetamide
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4094870 A1, 1978 ;
反应条件
sodium amide in toluene
参考文献
Krapcho,J. et al.
Journal of Medicinal Chemistry, 1963 , vol. 6, p. 544 - 546
参考文献
Marson
Farmaco, Edizione Scientifica, 1959 , vol. 14, p. 159,170
反应条件
potassium in tetrahydrofuran
参考文献
Osipenko,N.G. et al.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1977 , vol. 26, # 7 p. 1448 - 1452
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1977 , vol. 26, # 7 p. 1578 - 1581
反应条件
(i) NaOEt, EtOH, (ii) /BRN= 605280/; Multistep reaction;
参考文献
Unterhalt; Thamer
Archiv der Pharmazie, 1976 , vol. 309, # 10 p. 804 - 811
反应条件
(i) NaOEt, EtOH, (ii) /BRN= 605280/; Multistep reaction;
参考文献
Unterhalt; Thamer
Archiv der Pharmazie, 1976 , vol. 309, # 10 p. 804 - 811
