3,3-二甲基-1-丁酸合成路线 （共 132 条）
参考文献
Talaty,E.R. et al.
Tetrahedron Letters, 1978 , # 39 p. 3665 - 3668
反应条件
lithium aluminium tetrahydride in diethyl ether 12 h; Heating;
参考文献
Angelis, Yiannis S.; Orfanopoulos, Michael
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 6083 - 6085
反应条件
hydrogen sulfide; chlorine
参考文献
Chemische Werke Huels, A.G.
Patent: US4433175 A1, 1984 ;
反应条件
1: 80 percent / LiAlH4 / diethyl ether 2: pyridine / 16 h / Ambient temperature 3: dimethylsulfoxide / 6 h / 80 - 90 °C View Scheme
参考文献
Yokohama; Miwa; Aibara; Fujiwara; Matsumoto; Nakayama; Iwamoto; Mori; Moroi; Tsukada; Isoda
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 9 p. 2391 - 2398
反应条件
(i) SOCl2, (ii) Br2, (iii) /BRN= 1098229/; Multistep reaction;
参考文献
Keul, Helmut; Pfeffer, Bernd; Griesbaum, Karl
Chemische Berichte, 1984 , vol. 117, # 6 p. 2193 - 2204
反应条件
1: Br2, P View Scheme
参考文献
Canceill,J. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 2653 - 2658
反应条件
diphenyl phosphoryl azide; triethylamine in acetonitrile Curtis reaction; 0.5 h; Heating;
参考文献
Sasse, Astrid; Stark, Holger; Reidemeister, Sibylle; Huels, Annette; Elz, Sigurd; Ligneau, Xavier; Ganellin, C. Robin; Schwartz, Jean-Charles; Schunack, Walter
Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4269 - 4274
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane
参考文献
Campos-Sandoval, Jose Angel; Redondo, Clara; Kinsella, Gemma K.; Pal, Akos; Jones, Geraint; Eyre, Gwen S.; Hirst, Simon C.; Findlay, John B. C.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4378 - 4387
反应条件
sulfuric acid 6 h; 100 deg C to 250 deg C;
参考文献
Quast, Helmut; Ach, Manfred; Kindermann, Markus K.; Rademacher, Paul; Schindler, Michael
Chemische Berichte, 1993 , vol. 126, # 2 p. 503 - 516
反应条件
1: 72.1 percent / LiAlH4 / tetrahydrofuran 2: 37.4 percent / PBr3 / diethyl ether; diethyl ether / 16 h / Ambient temperature View Scheme
参考文献
Quast, Helmut; Berneth, Claus-Peter
Chemische Berichte, 1983 , vol. 116, # 4 p. 1345 - 1363
