3,3-二甲基-1-丁酸合成路线 （共 132 条）
反应条件
1: With trimethylacetic anhydride in acetone 0.5 h; 2: With tris(4-methylphenyl)-phosphine; palladium diacetate in tetrahydrofuran; acetone Sonication; 3: With hydrogen in tetrahydrofuran; acetone T=80°C; P=38787.1 Torr; 24 h;
参考文献
Prakash, Indra; Augustine, Robert L.; Tanielyan, Setrak K.
Patent: US2004/210094 A1, 2004 ;
Location in patent: Page 2 ;
反应条件
1: oxalyl chloride / CH2Cl2 / 1.5 h / Ambient temperature 2: 78 percent / 1,8-diazabicyclo<5.4.0>undec-7-ene / dimethylformamide / 6 h / 80 °C View Scheme
参考文献
Armarego, Wilfred L. F.; Taguchi, Hiroyasu; Cotton, Richard G. H.; Battiston, Sandra; Leong, Lillian
European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 283 - 292
反应条件
1: t-butyl acetic acid With lithium diisopropyl amide in tetrahydrofuran
T=-15 - -5°C; Inert atmosphere;
2: With N,N'-dimethyl-N,N'-propyleneurea in tetrahydrofuran
T=5°C; 0.5 h;
3: ethyl iodide in tetrahydrofuran
T=20°C; 2 h;
参考文献
Hen, Naama; Bialer, Meir; Wlodarczyk, Bogdan; Finnell, Richard H.; Yagen, Boris
Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4177 - 4186
反应条件
1: SOCl2
2: diethyl ether
View Scheme
参考文献
Hommelen
Bulletin des Societes Chimiques Belges, 1933 , vol. 42, p. 243,249
反应条件
1: SOCl2
2: bromine
View Scheme
参考文献
Homeyer; Whitmore; Wallingford
Journal of the American Chemical Society, 1933 , vol. 55, p. 4209,4212
反应条件
sulfuric acid
T=40°C; 2 h; Yield given;
参考文献
Randriamahefa, S.; Deschamps, P.; Gallo, R.; Grangette, H.
Synthesis, 1985 , # 5 p. 493 - 495
反应条件
1: 80 percent / LiAlH4 / diethyl ether
2: pyridine / 16 h / Ambient temperature
View Scheme
参考文献
Lee, Sueg-Geun
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 7 p. 1361 - 1372
反应条件
(i) SOCl2, (ii) NH3; Multistep reaction;
参考文献
Homeyer; Whitmore; Wallingford
Journal of the American Chemical Society, 1933 , vol. 55, p. 4209,4212
反应条件
1: SOCl2
2: diethyl ether
3: LiAlH4 / diethyl ether
4: HCO2H
View Scheme
参考文献
Duhamel,L. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 1797 - 1804
反应条件
sulfuric acid
T=40°C; 2 h; Yield given;
参考文献
Randriamahefa, S.; Deschamps, P.; Gallo, R.; Grangette, H.
Synthesis, 1985 , # 5 p. 493 - 495
