3,3-二甲基-1-丁酸合成路线 （共 132 条）
反应条件
sodium; Petroleum ether; benzene
zuletzt auf Behandeln des abgekuehlten Reaktionsgemisches mit CO2 bei 44-63grad;
参考文献
Bush
Journal of the American Chemical Society, 1939 , vol. 61, p. 637
Full Text View citing articles Show Details
Mallinckrodt chem. Works
Patent: US2260800 , 1939 ;
反应条件
thorium(IV) dioxide
T=410 - 415°C;
参考文献
Lion, Claude; Dubois, Jacques-Emile; Lebbar, Khadija
Bulletin des Societes Chimiques Belges, 1986 , vol. 95, # 2 p. 119 - 126
反应条件
bromine; phosphorus trichoride
T=60 - 70°C; dann auf 100grad;
参考文献
Canceill,J. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 2653 - 2658
反应条件
1: 1.) n-butyl-lithium / 1.) tetrahydrofuran, di-isopropylamine, -78 deg C, 50 min; 2.) 3 h, r.t.
2: thionyl chloride / 1.5 h / 40 - 50 °C
View Scheme
参考文献
Atkinson, Robert S.; Tughan, Gary
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 2787 - 2796
反应条件
(i) SOCl2, (ii) Cl2, PCl3; Multistep reaction;
参考文献
Huston,R. et al.
Bulletin des Societes Chimiques Belges, 1979 , vol. 88, p. 911 - 921
反应条件
1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 2.33 h / 0 - 20 °C
2.1: dichloromethane; tetrahydrofuran / 20 °C / |Cooling with ice
3.1: toluene / 65 °C / |Schlenk technique; |Inert atmosphere
3.2: -78 °C / |Schlenk technique; |Inert atmosphere
3.3: 1 h / 20 °C / |Schlenk technique; |Inert atmosphere
View Scheme
参考文献
Kobeissi, Marwan; Cherry, Khalil; Jomaa, Wissam
Synthetic Communications, 2013 , vol. 43, # 21 p. 2955 - 2965
反应条件
1.1: 74 percent / H2SO4 / 24 h / 84 °C
2.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 4 h / -78 °C
2.2: 89 percent / tetrahydrofuran; hexane / 16 h / 23 °C
3.1: BH3*SMe2 / tetrahydrofuran / 72 h / 23 °C
3.2: 51 percent / NaOH; aq. H2O2 / tetrahydrofuran / 48 h / 23 °C
4.1: 81 percent / camphorsulfonic acid / benzene / 24 h / 80 °C
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
反应条件
hydrogenchloride
12 h; Reflux;
参考文献
Peifer, Manuel; Berger, Raphaelle; Shurtleff, Valerie W.; Conrad, Jay C.; Macmillan, David W. C.
Journal of the American Chemical Society, 2014 , vol. 136, # 16 p. 5900 - 5903
反应条件
1: SOCl2
2: auf dem Dampfbad
View Scheme
参考文献
Homeyer; Whitmore; Wallingford
Journal of the American Chemical Society, 1933 , vol. 55, p. 4209,4212
反应条件
1: t-butyl acetic acid With pyridine in tetrahydrofuran
T=0°C; 0.5 h;
2: chloro-trimethyl-silane With 1,1,1,3,3,3-hexamethyl-disilazane in tetrahydrofuran
T=0 - 20°C; 12 h;
参考文献
Rotzoll, Sven; Ullah, Ehsan; Goerls, Helmar; Fischer, Christine; Langer, Peter
Tetrahedron, 2007 , vol. 63, # 12 p. 2647 - 2656
