3,3-二甲基-1-丁酸合成路线 （共 132 条）
反应条件
hydrogen; silica gel; palladium
T=330°C;
参考文献
Maier, Wilhelm F.; Roth, Wolfgang; Thies, Irina; Schleyer, Paul Rague v.
Chemische Berichte, 1982 , vol. 115, # 2 p. 808 - 812
参考文献
Whitmore; Fleming
Journal of the American Chemical Society, 1933 , vol. 55, p. 3804
反应条件
1: 98 percent / Heating
2: 1) iPr2NLi / 1) THF, -78 deg C, 30 min, 2) -78 deg C to r.t.
3: ZnCl2 / CH2Cl2 / 24 h / Ambient temperature
View Scheme
参考文献
Lion, Claude; Dubois, Jacques-Emile
Tetrahedron, 1981 , vol. 37, p. 319 - 323
反应条件
1: 86 percent / SOCl2 / 20 h / 25 °C
2: 1.) 2,2-bipyridyl, n-BuLi / 1.) THF, hexane, from below -60 to -5 deg C, 2.) -70 deg C, 45 min
View Scheme
参考文献
House, Herbert O.; Outcalt, Russell J.; Cliffton, Michael D.
Journal of Organic Chemistry, 1982 , vol. 47, # 12 p. 2413 - 2419
反应条件
(i) Fe, H3BO3, (ii) (pyrolysis); Multistep reaction;
参考文献
Scholz, Stefan; Marschall-Weyerstahl, Helga; Weyerstahl, Peter
Liebigs Annalen der Chemie, 1985 , # 10 p. 1935 - 1950
参考文献
Quast, Helmut; Ach, Manfred; Kindermann, Markus K.; Rademacher, Paul; Schindler, Michael
Chemische Berichte, 1993 , vol. 126, # 2 p. 503 - 516
反应条件
1: 98 percent / Heating
2: 1) iPr2NLi / 1) THF, -78 deg C, 30 min, 2) -78 deg C to r.t.
View Scheme
参考文献
Lion, Claude; Dubois, Jacques-Emile
Tetrahedron, 1981 , vol. 37, p. 319 - 323
反应条件
1: (i) LDA, THF, (ii) /BRN= 1209232/
2: O2, tetraphenylporphyrin / Irradiation
3: MeOH
4: (reduction)
View Scheme
参考文献
Adam,W. et al.
Journal of the American Chemical Society, 1977 , vol. 99, # 17 p. 5768 - 5773
反应条件
Yield given. Multistep reaction;
参考文献
Corte, Filip A. J. De; Clercq, Pierre J. De
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 7 p. 493 - 504
反应条件
1: 84 percent / LiAlH4 / diethyl ether / 12 h / Heating
2: Et3N / CH2Cl2 / 0.5 h / -50 °C
3: neat (no solvent) / 120 °C
4: 1.) BuLi, 2.) O2 / 1.) THF, 2.) -40 deg C
View Scheme
参考文献
Angelis, Yiannis S.; Orfanopoulos, Michael
Journal of Organic Chemistry, 1997 , vol. 62, # 17 p. 6083 - 6085
