3,3-二甲基-1-丁酸合成路线 （共 132 条）
反应条件
1: LiAlH4
4: BuLi, molecular oxygen / tetrahydrofuran
View Scheme
参考文献
Angelis, Yiannis; Zhang, Xiaojun; Orfanopoulos, Michael
Tetrahedron Letters, 1996 , vol. 37, # 33 p. 5991 - 5994
反应条件
1.1: 74 percent / H2SO4 / 24 h / 84 °C
2.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 4 h / -78 °C
2.2: 89 percent / tetrahydrofuran; hexane / 16 h / 23 °C
3.1: BH3*SMe2 / tetrahydrofuran / 72 h / 23 °C
3.2: 51 percent / NaOH; aq. H2O2 / tetrahydrofuran / 48 h / 23 °C
4.1: 81 percent / camphorsulfonic acid / benzene / 24 h / 80 °C
5.1: DIBAL-H / toluene; CH2Cl2 / 5 h / -78 °C
6.1: 0.341 g / pyridine; 4-dimethylaminopyridine / toluene; CH2Cl2 / 24.5 h / -78 - 23 °C
View Scheme
参考文献
Ayala, Leticia; Lucero, Claudia G.; Antoinette, Jan; Romero; Tabacco, Sarah A.; Woerpel
Journal of the American Chemical Society, 2003 , vol. 125, # 50 p. 15521 - 15528
