3,3-二甲基-1-丁酸合成路线 （共 132 条）
反应条件
1: thionyl chloride / 1 h / Heating 2: Br2 / CCl4 / 3.5 h / Heating 3: CCl4; CH2Cl2 View Scheme
参考文献
Shimazu, Masako; Endo, Yasuyuki; Shudo, Koichi
Heterocycles, 1997 , vol. 45, # 4 p. 735 - 744
反应条件
1: (i) SOCl2, (ii) /BRN= 605257/ 2: LiAlH4 / diethyl ether / Heating View Scheme
参考文献
Duhamel,L. et al.
Bulletin de la Societe Chimique de France, 1970 , p. 1797 - 1804
反应条件
potassium carbonate in N,N-dimethyl-formamide T=20°C;
参考文献
Ter Wiel, Matthijs K. J.; Kwit, Marcin G.; Meetsma, Auke; Feringa, Ben L.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 1 p. 87 - 96
参考文献
Lion, Claude; Dubois, Jacques-Emile
Tetrahedron, 1981 , vol. 37, p. 319 - 323
反应条件
1: SOCl2 View Scheme
参考文献
Homeyer; Whitmore; Wallingford
Journal of the American Chemical Society, 1933 , vol. 55, p. 4209,4212
参考文献
House,H.O. et al.
Journal of Organic Chemistry, 1978 , vol. 43, p. 700 - 710
反应条件
1: 80 percent / LiAlH4 / diethyl ether 2: 56 percent / conc. aq. HCl, ZnCl2 View Scheme
参考文献
Lee, Sueg-Geun
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 7 p. 1361 - 1372
参考文献
Hellmann,G. et al.
Chemische Berichte, 1979 , vol. 112, p. 1808 - 1834
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide 1.) 0 deg C, THF; 2.) 0 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Hen, Naama; Bialer, Meir; Wlodarczyk, Bogdan; Finnell, Richard H.; Yagen, Boris
Journal of Medicinal Chemistry, 2010 , vol. 53, # 10 p. 4177 - 4186
反应条件
1: 80 percent / LiAlH4 / diethyl ether 2: pyridine / 16 h / Ambient temperature 3: dimethylsulfoxide / 6 h / 80 - 90 °C 4: aq. KOH / ethanol / 2 h / Heating View Scheme
参考文献
Lee, Sueg-Geun
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1993 , # 7 p. 1361 - 1372
