3-羟基呋喃并[3,2-b]吡啶-2-羧酸乙酯合成路线 （共 6 条）
反应条件
sodium ethanolate in toluene 18 h; Heating;
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 665 - 668
反应条件
1: 85 percent / sulfuric acid / benzene / 40 h / Heating 2: 84 percent / K2CO3 / acetone / 15 h / Heating 3: 91 percent / C2H5ONa / toluene / 18 h / Heating View Scheme
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 665 - 668
反应条件
1: 84 percent / K2CO3 / acetone / 15 h / Heating 2: 91 percent / C2H5ONa / toluene / 18 h / Heating View Scheme
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 665 - 668
反应条件
hydrogenchloride in water 3 h; Heating / reflux;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2005/42538 A1, 2005 ;
Location in patent: Page/Page column 15; 16 ;
WO 2005/042538 A1
反应条件
1: HCl / H2O / 3 h / Heating 2: NaBH4 / methanol / 0.5 h / Ambient temperature 3: 94 percent / H3PO4 (85percent) / 15 h / 170 - 180 °C View Scheme
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki
Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 665 - 668
反应条件
1: 75 percent / K2CO3 / acetone / 5 h / Heating
2: 72 percent / NaOEt / toluene; ethanol / 2 h / Heating
3: KOH / H2O; ethanol / 1 h / Heating
View Scheme
参考文献
Shiotani, Shunsaku; Morita, Hiroyuki; Ishida, Toshimasa; In, Yasuko
Journal of Heterocyclic Chemistry, 1988 , vol. 25, p. 1205 - 1213
