1: 2-picoline, magnesium triflate / toluene / 1 h / Heating 2: 23 percent / K2CO3, FClO3 3: 74 percent / 2,6-lutidine, magnesium triflate, tert-butyltoluene / 0.17 h / Heating 4: 98 percent / 1 M Bu4NF / tetrahydrofuran / 22 h / Ambient temperature 5: 263 mg / 1 N aq. NaOH / methanol / Ambient temperature View Scheme

Multi-step reaction with 2 steps 1: 2-picoline, magnesium triflate / toluene / 1 h / Heating2: 23 percent / K2CO3, FClO3  

Multi-step reaction with 3 steps 1: 2-picoline, magnesium triflate / toluene / 1 h / Heating2: 23 percent / K2CO3, FClO3 3: 74 percent / 2,6-lutidine, magnesium triflate, tert-butyltoluene / 0.17 h / Heating  

Multi-step reaction with 2 steps 1: 2-picoline, magnesium triflate / toluene / 1 h / Heating2: 1.) Cs2CO3, FClO3, CH3OH, 2.) 2-picoline, magnesium triflate / 1.) 15 deg C, 1 h, 2.) xylene, reflux, 4 h