反应条件
1: propanedioic acid monoethyl ester With methylmagnesium bromide in tetrahydrofuran; diethyl ether 0.333333 h; 2: imidazol-1-yl-(2,4,5-trifluoro-phenyl)-methanone in tetrahydrofuran; diethyl ether T=60°C; 3: With hydrogenchloride in tetrahydrofuran; diethyl ether pH=5 - 6; Further stages.;
参考文献
Tomita, Kyoji; Tsuzuki, Yasunori; Shibamori, Koh-ichiro; Tashima, Masanori; Kajikawa, Fumie; Sato, Yuji; Kashimoto, Shigeki; Chiba, Katsumi; Hino, Katsuhiko
Journal of Medicinal Chemistry, 2002 , vol. 45, # 25 p. 5564 - 5575