6-氯-6-氧代己酸乙酯合成路线 （共 76 条）
反应条件
1: 95 percent / triethylamine, 4-(dimethylamino)pyridine / acetonitrile / 2 h / Ambient temperature
2: 43 percent / borane / 1,2-dimethoxy-ethane / 0.33 h
3: 100 percent / Na2CO3 / H2O; methanol / Ambient temperature
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参考文献
Delaney, Edward J.; Wood, Leigh E.; Klotz, Irving M.
Journal of the American Chemical Society, 1982 , vol. 104, # 3 p. 799 - 807
反应条件
1: 1) Friedel-Crafts reaction
2: hydrazine hydrate
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参考文献
Reynders, Peter; Kuehnle, Wolfgang; Zachariasse, Klaas A.
Journal of Physical Chemistry, 1990 , vol. 94, # 10 p. 4073 - 4082
参考文献
Bullock et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 1828,1830
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Bullock et al.
Journal of the American Chemical Society, 1957 , vol. 79, p. 1975,1976
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Soper et al.
Journal of the American Chemical Society, 1954 , vol. 76, p. 4109,4111
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Reed; Niu
Journal of the American Chemical Society, 1955 , vol. 77, p. 416,418
反应条件
(i) AlCl3, CCl4, (ii) /BRN= 1730731/; Multistep reaction;
参考文献
Kugatova-Shemyakina,G.P. et al.
Zhurnal Organicheskoi Khimii, 1967 , vol. 3, p. 1213 - 1220,1175 - 1180
反应条件
2: diethyl ether / Erhitzen des Reaktionsprodukts mit wenig Jod bis auf 180grad, anschliessenden Hydrieren an Palladium in Aethanol und Erwaermen des Reaktionsgemisches mit aethanol.Kalilauge
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参考文献
Moroe
Yakugaku Zasshi, 1950 , vol. 70, p. 416,422
Yakugaku Zasshi, 1951 , vol. 71, p. 123
反应条件
1: AlCl3 / various solvent(s) / 17 h / 110 - 120 °C / other solvent: nitrobenzene
2: 95.4 percent / Zn-Hg, conc. HCl / toluene / 15 h / Heating
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参考文献
Okamoto; Watanabe; Kawada; Goto; Ashida; Oda; Yajima; Imada; Morimoto
Chemical and pharmaceutical bulletin, 1982 , vol. 30, # 8 p. 2797 - 2819
反应条件
1: 1.) AlCl3, 2.) 12percent methanolic KOH / 1.) nitrobenzene, 0 deg C, 6 h, RT, 64 h
2: 53.6 percent / ON(SO3K)2, KH2PO4 / acetone; H2O / 3 h / Ambient temperature
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参考文献
Takeda Chemical Industries
Patent: FR2269333DE2519730 , 19751975 ;
Chem.Abstr., 1976 , vol. 84, # 58928
反应条件
1: 76 percent / tin(IV) chloride / CH2Cl2 / 1.5 h / Ambient temperature
2: 91 percent / 95percent hydrazine hydrate, potassium hydroxide / ethane-1,2-diol / 4.5 h / 60 °C / Heating
3: 85 percent / Raney nickel-aluminium alloy / aq. NaOH / 3 h / 90 - 120 °C
4: 93 percent / lithium aluminium hydride / diethyl ether / 1.) RT, 1.5 h, 2.) reflux, 1h
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参考文献
Jefferson, Alan; Sargent, Melvyn V.; Wangchareontrakul, Sirichai
Australian Journal of Chemistry, 1988 , vol. 41, # 1 p. 19 - 25
反应条件
1: anschliessend Hydrolyse
2: N2H4+H2O; diethylene glycol / 135 °C / anschliessend Erhitzen mit KOH auf 230grad
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参考文献
Huisgen et al.
Chemische Berichte, 1957 , vol. 90, p. 1958,1965
反应条件
1: toluene; AlCl3 / Erwaermen des Reaktionsprodukts mit wss.-aethanol. KOH
2: N2H4+H2O; diethylene glycol / 135 °C / anschliessend Erhitzen mit KOH auf 220grad
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参考文献
Huisgen; Vossius
Monatshefte fuer Chemie, 1957 , vol. 88, p. 517,527
