(1S,2R,3S,4R)-双环[2.2.1]庚烷-2-羧酸合成路线 （共 2 条）
反应条件
sodium acetate; sodium cyanoborohydride; silica gel in methanol; sodium hydrogencarbonate; ethyl acetate
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
Location in patent: Page/Page column 92-93 ;
反应条件
1.1: QNH / toluene; tetrachloromethane / Inert atmosphere 1.2: -55 - 25 °C 2.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0 °C / Inert atmosphere 2.2: 0 - 25 °C 3.1: hydrogen / 5 palladium on charcoal / ethyl acetate / 16 h / 25 °C 4.1: sodium acetate; sodium cyanoborohydride / methanol / 16 h / 25 °C / Molecular sieve View Scheme
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
