7-氯-2-碘呋喃并[3,2-b]吡啶合成路线 （共 4 条）
反应条件
potassium fluoride; N-iodo-succinimide in acetonitrile T=20 - 50°C; 2 h; Inert atmosphere;
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2013/124025 A1, 2013 ;
Location in patent: Page/Page column 73; 74 ;
反应条件
1.1: copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 0.08 h / Inert atmosphere 1.2: 18 h / 500 °C 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C 3.1: trichlorophosphate / 2 h / 100 °C / Sealed tube 4.1: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere View Scheme
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2013/124025 A1, 2013 ;
反应条件
1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C 2: trichlorophosphate / 2 h / 100 °C / Sealed tube 3: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere View Scheme
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2013/124025 A1, 2013 ;
反应条件
1: trichlorophosphate / 2 h / 100 °C / Sealed tube 2: potassium fluoride; N-iodo-succinimide / acetonitrile / 2 h / 20 - 50 °C / Inert atmosphere View Scheme
参考文献
MERCK PATENT GMBH; BURGDORF, Lars; ROSS, Tatjana; DEUTSCH, Carl
Patent: WO2013/124025 A1, 2013 ;
