(-)-(S)-5-溴-2,3-二甲氧基-n-[(1-乙基-2-吡咯烷)甲基]-苯甲酰胺合成路线 （共 6 条）
反应条件
1: SOCl2; DMF / toluene / 2 h / 80 °C 2: 3.18 g / CH2Cl2 / 20 °C View Scheme
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
in dichloromethane 4 h; Ambient temperature;
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
1: 72 percent / KMnO4; K2HPO4*3H2O / 2-methyl-propan-2-ol; H2O / 0.5 h 2: SOCl2; DMF / toluene / 2 h / 80 °C 3: 3.18 g / CH2Cl2 / 20 °C View Scheme
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
1: 93 percent / K2CO3 / butan-2-one / 2 h / 80 °C 2: 72 percent / KMnO4; K2HPO4*3H2O / 2-methyl-propan-2-ol; H2O / 0.5 h 3: SOCl2; DMF / toluene / 2 h / 80 °C 4: 3.18 g / CH2Cl2 / 20 °C View Scheme
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
1: 85 percent / Br2, KBr, acetic acid / 0.33 h / 110 °C 2: 91 percent / K2CO3 / acetone / 16 h / Heating 3: 75 percent / AgNO3, 1N aq. NaOH / methanol / 5 h / 85 °C 4: 94 percent / SOCl2, DMF / toluene / 0.67 h / 60 °C 5: 78 percent / CH2Cl2 / 4 h / Ambient temperature View Scheme
参考文献
De Paulis; Smith
Synthetic Communications, 1991 , vol. 21, # 8-9 p. 1091 - 1095
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Hogberg; Strom; Hall; Ogren
Helvetica Chimica Acta, 1990 , vol. 73, # 2 p. 417 - 425
