1,3,2-二噁唑噻吩-2,2-二氧化物合成路线 （共 24 条）
反应条件
1: MeSCF2P(O)(Oi-Pr)2 With tert.-butyl lithium in tetrahydrofuran; pentane
T=-78°C;
2: ethylene glycol cyclic sulfate in tetrahydrofuran; pentane
T=-78°C; 0.25 h;
3: With sulfuric acid; water in tetrahydrofuran; pentane
T=-78 - 20°C;
参考文献
Diab, Sonia Amel; Sene, Aboubacary; Pfund, Emmanuel; Lequeux, Thierry
Organic Letters, 2008 , vol. 10, # 17 p. 3895 - 3898
反应条件
1: (4-chloro-phenyl)-acetic acid With lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 20°C; 1.08333 h; Inert atmosphere;
2: ethylene glycol cyclic sulfate in tetrahydrofuran; ethylene glycol dimethyl ether; hexane
16 h; Inert atmosphereReflux;
参考文献
Birrell, James A.; Desrosiers, Jean-Nicolas; Jacobsen, Eric N.
Journal of the American Chemical Society, 2011 , vol. 133, # 35 p. 13872 - 13875
反应条件
1: 1-methyl-1H-pyrazole With n-butyllithium in tetrahydrofuran; hexane
T=-78 - 0°C;
2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexane
T=20°C; 48 h;
3: With sulfuric acid in tetrahydrofuran; hexane
16 h; Heating; Further stages.;
参考文献
Schlaeger, Torsten; Oberdorf, Christoph; Tewes, Bastian; Wuensch, Bernhard
Synthesis, 2008 , # 11 p. 1793 - 1797
反应条件
1: pentadiene-1,4 With n-butyllithium; potassium tert-butylate in tetrahydrofuran; hexane
T=0°C; 0.333333 h;
2: ethylene glycol cyclic sulfate in tetrahydrofuran; hexane
T=-75°C;
参考文献
Schlosser; Zellner; Leroux
Synthesis, 2001 , # 12 p. 1830 - 1836
