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乙二醇
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63148-62-9
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二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
2-氨基-5-溴吡啶
合成路线
（共 208 条）
1072-97-5
2-氨基-5-溴吡啶
→
反应条件
918516-27-5
5-(4-氯苯基)-1H-吡咯并[2,3-b]吡啶
反应条件
1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct; palladium diacetate / 1,4-dioxane; water / 1.5 h / 90 °C 2: trifluoroacetic acid; N-iodo-succinimide / N,N-dimethyl-formamide / 2.5 h / 80 °C 3: lithium hydroxide hydrate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / N,N-dimethyl-formamide / 18 h / 70 °C / Inert atmosphere 4: hydrogenchloride / water / 1 h / 50 °C / Inert atmosphere View Scheme
参考文献
F. HOFFMANN-LA ROCHE AG; BRUMSTED, Corey James; MOORLAG, Hendrik; RADINOV, Roumen Nikolaev; REN, Yi; WALDMEIER, Pius
Patent: WO2012/10538 A2, 2012 ;
1072-97-5
2-氨基-5-溴吡啶
+
151169-75-4
3,4-二氯苯硼酸
→
反应条件
926224-90-0
反应条件
palladium diacetate; sodium carbonate in water; N,N-dimethyl-formamide T=110°C; Suzuki coupling; 3 h;
参考文献
Heitman, Laura H.; Van Veldhoven, Jacobus P. D.; Zweemer, Annelien M.; Ye, Kai; Brussee, Johannes; Ijzerrnan, Adriaan P.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4724 - 4729
1072-97-5
2-氨基-5-溴吡啶
+
927-58-2
4-溴丁酰氯
→
反应条件
928775-04-6
1-(5-溴-2-吡啶基)-2-吡咯烷酮
反应条件
potassium carbonate in acetonitrile T=20°C; Inert atmosphere;
参考文献
EUROSCREEN S.A.; HOVEYDA, Hamid; DUTHEUIL, Guillaume; EL BOUSMAQUI, Mohamed; BERNARD, Jerome
Patent: WO2011/151434 A1, 2011 ;
Location in patent: Page/Page column 53 ;
WO 2011/151434 A1
1072-97-5
2-氨基-5-溴吡啶
+
124-38-9
二氧化碳
+
100-39-0
→
反应条件
935687-49-3
反应条件
1: 5-bromopyridin-2-yl amine; carbon dioxide With magnesium; 1-n-butyl-3-methylimidazolium tetrafluoroborate T=50°C; Electrochemical reactionInert atmosphere; 2: benzyl bromide With potassium carbonate T=55°C; 12 h; Ionic liquidInert atmosphere;
参考文献
Feng, Qiuju; Huang, Kelong; Liu, Suqin; Wang, Xuanyun
Electrochimica Acta, 2010 , vol. 55, # 20 p. 5741 - 5745
1072-97-5
2-氨基-5-溴吡啶
→
反应条件
943419-35-0
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 0 - 20 °C 2: [Cp*RhCl2]2; silver hexafluoroantimonate; copper diacetate / 1,2-dichloro-ethane / 24 h / 120 °C / |Schlenk technique; |Inert atmosphere 3: hydrogenchloride / |Reflux View Scheme
参考文献
Zhou, Jun; Li, Bo; Hu, Fang; Shi, Bing-Feng
Organic Letters, 2013 , vol. 15, # 13 p. 3460 - 3463
1072-97-5
2-氨基-5-溴吡啶
→
反应条件
953414-71-6
反应条件
1: iodine; KIO3; sulfuric acid; acetic acid / water / 8 h / 80 °C 2: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 20 °C / |Inert atmosphere View Scheme
参考文献
Leboho, Tlabo C.; Van Vuuren, Sandy F.; Michael, Joseph P.; De Koning, Charles B.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 2 p. 307 - 315
1072-97-5
2-氨基-5-溴吡啶
+
403-29-2
→
反应条件
426825-66-3
反应条件
in ethanol 5 h; Heating;
参考文献
Enguehard, Cecile; Hervet, Maud; Thery, Isabelle; Renou, Jean-Louis; Fauvelle, Florence; Gueiffier, Alain
Helvetica Chimica Acta, 2001 , vol. 84, # 12 p. 3610 - 3615
1072-97-5
2-氨基-5-溴吡啶
→
反应条件
431942-30-2
反应条件
1.1: NaNO2 / H2SO4; H2O / 0.5 h / 0 - 5 °C 1.2: 82 percent / CuSO4*5H2O / H2O / Heating 2.1: 74 percent / N-iodosuccinimide / methanol / 10 h / 50 °C 3.1: 72 percent / (Ph2P)2PdCl2; CuI / triethylamine / 10 h / 100 °C View Scheme
参考文献
Van De Poel, Herve; Guillaumet, Gerald; Viaud-Massuard, Marie-Claude
Heterocycles, 2002 , vol. 57, # 1 p. 55 - 71
1072-97-5
2-氨基-5-溴吡啶
+
638-07-3
→
反应条件
442531-33-1
反应条件
PPA T=110°C; 0.5 h;
参考文献
Montana, Marc; Crozet, Maxime D.; Castera-Ducros, Caroline; Terme, Thierry; Vanelle, Patrice
Heterocycles, 2008 , vol. 75, # 4 p. 925 - 932
1072-97-5
2-氨基-5-溴吡啶
+
67-64-1
→
反应条件
443339-43-3
反应条件
1: With acetic acid in dichloromethane T=20°C; 0.25 h; 2: With sodium tris(acetoxy)borohydride in dichloromethane T=0 - 20°C; 6 h;
参考文献
SHIONOGI and CO., LTD.
Patent: EP1354877 A1, 2003 ;
Location in patent: Page/Page column 14 ;
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