[(1S)-(1-(S)-N-Boc-氨基-2-环己基乙基)环氧乙烷合成路线 （共 5 条）
反应条件
sodium hydroxide in ethanol 1 h;
参考文献
VITAE PHARAMCEUTICALS, INC.
Patent: WO2007/117557 A2, 2007 ;
Location in patent: Page/Page column 92 ;
WO 2007/117557 A2
反应条件
triphenylphosphine; diethylazodicarboxylate in chloroform Heating;
参考文献
Castejon, Patricia
Tetrahedron Letters, 1995 , vol. 36, # 17 p. 3019 - 3022
反应条件
1: 4-methylmorpholine / tetrahydrofuran / 0.33 h / -25 - -20 °C 2: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight 3: HCl / dioxane; diethyl ether / 1 h / 0 °C 4: NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 5: KOH / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768
反应条件
1: HCl / dioxane; diethyl ether / 1 h / 0 °C 2: NaBH4 / tetrahydrofuran; H2O / 0.75 h / 0 °C 3: KOH / ethanol / 1.5 h / Ambient temperature View Scheme
参考文献
Barrish, Joel C.; Gordon, Eric; Alam, Masud; Lin, Pin-Fang; Bisacchi, Gregory S.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 12 p. 1758 - 1768
反应条件
sodium hydride 1.) DMSO, RT, 2.) DMSO, THF, 1 h; Yield given. Multistep reaction;
参考文献
Paige Souder; Evans, Zachary M.; Driver, Joshua A.; Pozzo, Eric J.; Lampkins, Andrew J.
Tetrahedron Letters, 2011 , vol. 52, # 51 p. 6908 - 6910
