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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
1072103-29-7
合成路线
（共 7 条）
1301214-68-5
→
反应条件
1072103-29-7
反应条件
1: With potassium hydroxide Reflux; 2: With hydrogenchloride in water
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
Location in patent: Page/Page column 30 ;
60891-70-5
(5-硝基吡啶-2-基)丙二酸二乙酯
→
反应条件
1072103-29-7
反应条件
1.1: nitric acid / 15 h / Reflux 2.1: sulfuric acid / 5 h / Reflux 3.1: 1 h / Reflux 4.1: hydrogen / palladium 10 on activated carbon / acetic acid / 760.05 Torr 5.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 °C 5.2: 0.25 h 6.1: sodium t-butanolate / palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / toluene / 2 h / 95 °C / Inert atmosphere 7.1: potassium hydroxide / Reflux View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
4548-45-2
2-氯-5-硝基吡啶
→
反应条件
1072103-29-7
反应条件
1.1: sodium hydride / tetrahydrofuran; mineral oil 1.2: 2 h / Reflux 2.1: nitric acid / 15 h / Reflux 3.1: sulfuric acid / 5 h / Reflux 4.1: 1 h / Reflux 5.1: hydrogen / palladium 10 on activated carbon / acetic acid / 760.05 Torr 6.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 °C 6.2: 0.25 h 7.1: sodium t-butanolate / palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / toluene / 2 h / 95 °C / Inert atmosphere 8.1: potassium hydroxide / Reflux View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
29682-14-2
5-硝基吡啶-2-甲酸甲酯
→
反应条件
1072103-29-7
反应条件
1.1: 1 h / Reflux 2.1: hydrogen / palladium 10 on activated carbon / acetic acid / 760.05 Torr 3.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 °C 3.2: 0.25 h 4.1: sodium t-butanolate / palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / toluene / 2 h / 95 °C / Inert atmosphere 5.1: potassium hydroxide / Reflux View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
30651-24-2
5-硝基-2-吡啶羧酸
→
反应条件
1072103-29-7
反应条件
1.1: sulfuric acid / 5 h / Reflux 2.1: 1 h / Reflux 3.1: hydrogen / palladium 10 on activated carbon / acetic acid / 760.05 Torr 4.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 °C 4.2: 0.25 h 5.1: sodium t-butanolate / palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / toluene / 2 h / 95 °C / Inert atmosphere 6.1: potassium hydroxide / Reflux View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
1301214-66-3
→
反应条件
1072103-29-7
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 0.17 h / 0 °C 1.2: 0.25 h 2.1: sodium t-butanolate / palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / toluene / 2 h / 95 °C / Inert atmosphere 3.1: potassium hydroxide / Reflux View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
1301214-67-4
→
反应条件
1072103-29-7
反应条件
1: sodium t-butanolate / palladium diacetate; biphenyl-2-yl-di-tert-butyl-phosphane / toluene / 2 h / 95 °C / Inert atmosphere 2: potassium hydroxide / Reflux View Scheme
参考文献
PFIZER INC.; BAGLEY, Scott William; GRIFFITH, David Andrew; KUNG, Daniel Wei-Shung
Patent: WO2011/58473 A1, 2011 ;
