3,6-二氯-4-乙基吡嗪合成路线 (共 3 条)
反应条件
(NH4)2S2O8; sulfuric acid; silver nitrate in water T=50 - 75°C; 0.833333 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/78136 A1, 2007 ;
Location in patent: Page/Page column 70-71 ;
US 20070078136 A1
反应条件
1: With (NH4)2S2O8; sulfuric acid; silver nitrate in water T=60 - 70°C; Inert atmosphere; 2: With ammonium hydroxide in water pH=7; Cooling with ice;
参考文献
SANOFI-AVENTIS
Patent: US2011/34452 A1, 2011 ;
Location in patent: Page/Page column 34 ;
反应条件
sulfuric acid; silver nitrate; propionic acid in water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US5482939 A1, 1996 ;