1-[[(1,1-二甲基乙氧基)羰基]氨基]环丙烷羧酸乙酯合成路线 （共 8 条）
反应条件
potassium hydrogencarbonate in water; ethyl acetate T=0 - 20°C; 16 h;
参考文献
Bridger, Gary; Skerlj, Renato; Kaller, Ai; Harwig, Curtis; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher Dennis; Di Fluri, Maria Rosaria
Patent: US2003/220341 A1, 2003 ;
Location in patent: Page/Page column 49-50 ;
US 20030220341 A1
反应条件
diphenyl phosphoryl azide; triethylamine T=20°C; 5 h; Heating / reflux;
参考文献
Wyeth
Patent: US2008/45556 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 7 p. 2151 - 2155
参考文献
Wheeler, Thomas N.; Ray, John A.
Synthetic Communications, 1988 , vol. 18, # 2 p. 141 - 150
反应条件
hydrogenchloride in ethyl acetate T=20°C; 1 h;
参考文献
Wyeth
Patent: US2008/45556 A1, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
sodium hydroxide in ethanol; water 72 h; Ambient temperature;
参考文献
Wheeler, Thomas N.; Ray, John A.
Synthetic Communications, 1988 , vol. 18, # 2 p. 141 - 150
反应条件
diisopropyl aluminium hydride in hexane T=-65°C; 4 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 42, # 7 p. 1442 - 1454
反应条件
lithium borohydride in tetrahydrofuran Ambient temperature;
参考文献
Wentland; Perni; Dorff; Rake
Journal of Medicinal Chemistry, 1988 , vol. 31, # 9 p. 1694 - 1697
