6-[(2,2,2-三氟乙氧基)甲基]烟酸合成路线 （共 2 条）
反应条件
1: 2,2,2-trifluoroethanol With potassium hydroxide; Aliquatreg; 336 in dichloromethane T=30°C; 0.25 h; Inert atmosphere; 2: methyl 6-{[(methylsulfonyl)oxy]methyl}pyridine-3-carboxylate in dichloromethane 0.25 h;
参考文献
ASTRAZENECA AB; AURELL, Carl-Johan; BESIDSKI, Yevgeni; KERS, Inger; NYLOeF, Martin
Patent: WO2012/39657 A1, 2012 ;
Location in patent: Page/Page column 14 ;
WO 2012/039657 A1
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 1 h / -78 °C / Inert atmosphere 2.1: potassium hydroxide / Aliquatreg; 336 / dichloromethane / 0.25 h / 30 °C / Inert atmosphere 2.2: 0.25 h View Scheme
参考文献
ASTRAZENECA AB; AURELL, Carl-Johan; BESIDSKI, Yevgeni; KERS, Inger; NYLOeF, Martin
Patent: WO2012/39657 A1, 2012 ;
WO 2012/039657 A1
