N-甲酰基-L-异亮氨酸 (1S)-1-[[(2S,3S)-3-己基-4-氧代-2-氧杂环丁基]甲基]十二烷基酯合成路线 （共 7 条）
反应条件
triethylamine in dichloromethane T=20°C; 0.25 h;
参考文献
Ortar, Giorgio; Bisogno, Tiziana; Ligresti, Alessia; Morera, Enrico; Nalli, Marianna; Di Marzo, Vincenzo
Journal of Medicinal Chemistry, 2008 , vol. 51, # 21 p. 6970 - 6979
反应条件
in dichloromethane T=-10 - -5°C; 2 h;
参考文献
NORTHEASTERN UNIVERSITY; DUCLOS, Richard, I.
Patent: WO2013/177492 A2, 2013 ;
Location in patent: Paragraph 0137 ;
反应条件
1: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran 2: dichloromethane View Scheme
参考文献
Johnston, Meghan; Bhatt, Shachi R.; Sikka, Surina; Mercier, Richard W.; West, Jay M.; Makriyannis, Alexandros; Gatley, S. John; Duclos Jr., Richard I.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4585 - 4592
反应条件
1: sodium hydroxide / 1,4-dioxane 2: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane 3: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran 4: dichloromethane View Scheme
参考文献
Johnston, Meghan; Bhatt, Shachi R.; Sikka, Surina; Mercier, Richard W.; West, Jay M.; Makriyannis, Alexandros; Gatley, S. John; Duclos Jr., Richard I.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4585 - 4592
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane 2: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran 3: dichloromethane View Scheme
参考文献
Johnston, Meghan; Bhatt, Shachi R.; Sikka, Surina; Mercier, Richard W.; West, Jay M.; Makriyannis, Alexandros; Gatley, S. John; Duclos Jr., Richard I.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4585 - 4592
反应条件
1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane 2: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran 3: dichloromethane View Scheme
参考文献
Johnston, Meghan; Bhatt, Shachi R.; Sikka, Surina; Mercier, Richard W.; West, Jay M.; Makriyannis, Alexandros; Gatley, S. John; Duclos Jr., Richard I.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4585 - 4592
参考文献
Johnston, Meghan; Bhatt, Shachi R.; Sikka, Surina; Mercier, Richard W.; West, Jay M.; Makriyannis, Alexandros; Gatley, S. John; Duclos Jr., Richard I.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4585 - 4592
