4,4-二甲基-2-环己基-1-酮合成路线 （共 63 条）
反应条件
1: 96 percent / H2 / Pd/C / ethyl acetate / 759.8 Torr
2: 85 percent / NaH, KH / tetrahydrofuran
View Scheme
参考文献
Liu, Hsing-Jang; Browne, Eric N. C.; Chew, Sew Yeu
Canadian Journal of Chemistry, 1988 , vol. 66, p. 2345 - 2347
反应条件
1: 4,4-dimethyl-cyclohex-2-en-1-one With lithium diisopropyl amide in tetrahydrofuran
T=-78°C; 1 h;
2: chloro-trimethyl-silane in tetrahydrofuran
T=-78 - 20°C;
参考文献
Futagawa, Tohru; Nishiyama, Norio; Tai, Akira; Okuyama, Tadashi; Sugimura, Takashi
Tetrahedron, 2002 , vol. 58, # 45 p. 9279 - 9287
参考文献
Lidert, Zev; Williams, Simon F.
Tetrahedron Letters, 1988 , vol. 29, # 12 p. 1347 - 1350
参考文献
Liu,H.-J.; Yao,C.-L.
Canadian Journal of Chemistry, 1977 , vol. 55, p. 822 - 830
反应条件
in toluene
azeotropic removal of water;
参考文献
Kigler, Ralf; Margaretha, Paul
Organic Magnetic Resonance, 1984 , vol. 22, # 8 p. 536 - 538
反应条件
in diethyl ether
T=-78 - 20°C;
参考文献
BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; GREENWOOD, Jeremy, R.; FRYE, Leah, L.
Patent: WO2013/82000 A1, 2013 ;
Location in patent: Page/Page column 80; 81 ;
参考文献
BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd
Patent: WO2010/147653 A1, 2010 ;
Location in patent: Page/Page column 174 ;
反应条件
1: hydrogen / 5percent Pd-C / ethanol
2: 94 percent / chlorine / CCl4; dimethylformamide / 40 °C
3: 98 percent / dimethylformamide / 0.25 h / 120 - 140 °C
View Scheme
参考文献
Buyck, Laurent De; Verhe, Roland; Kimpe, Norbert De; Schamp, Niceas
Bulletin des Societes Chimiques Belges, 1982 , vol. 91, # 9 p. 797 - 802
反应条件
1.1: dihydrogen peroxide / methanol; water / 0.83 h / 20 °C
1.2: 3.75 h / 15 - 20 °C
2.1: sodium tetrahydroborate / methanol / 3.75 h / 0 - 20 °C / |Inert atmosphere
3.1: lithium bromide; tris-(dimethylamino)-phosphine / toluene / 3.33 h / 20 °C / |Reflux; |Inert atmosphere
View Scheme
参考文献
Kraft, Philip; Jordi, Samuel; Denizot, Natacha; Felker, Irene
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 554 - 563
反应条件
1: 4,4-dimethyl-cyclohex-2-en-1-one With n-butyllithium; diisopropylamine in tetrahydrofuran
T=-78°C; 1.16667 h;
2: acetic anhydride in tetrahydrofuran
T=-78°C; 0.5 h;
参考文献
Romanski, Steffen; Kraus, Birgit; Guttentag, Miguel; Schlundt, Waldemar; Ruecker, Hannelore; Adler, Andreas; Neudoerfl, Joerg-Martin; Alberto, Roger; Amslinger, Sabine; Schmalz, Hans-Guenther
Dalton Transactions, 2012 , vol. 41, # 45 p. 13862 - 13875
