2,4-二甲基-3-氨基吡啶合成路线 （共 10 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=3102.9 Torr; 2 h;
参考文献
Wang, Yuqiang; Liu, Mao-Chin; Lin, Tai-Shun; Sartorelli, Alan C.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3667 - 3671
反应条件
1: With thionyl chloride T=60°C; 1 h; 2: With sodium azide; water in acetone T=70°C; 1 h;
参考文献
VALEANT PHARMACEUTICALS INTERNATIONAL
Patent: US2008/318979 A1, 2008 ;
Location in patent: Page/Page column 20 ;
US 20080318979 A1
反应条件
ammonium hydroxide; hydrogen; palladium on activated charcoal in methanol P=2206.5 Torr;
参考文献
Sawanishi, Hiroyuki; Tajima, Kayoko; Tsuchiya, Takashi
Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 10 p. 4101 - 4109
反应条件
1: 19 percent / fuming sulfuric acid, potassium nitrate / 16 h / 100 - 120 °C 2: 98 percent / H2 / 5percent Pd/C / ethanol / 2 h / 3102.9 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 20 p. 3667 - 3671
反应条件
1: POCl3 / 7 h / Heating 2: 92 percent / conc. ammonia, hydrogen / 5percent Pd-C / methanol / 2206.5 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 35, # 10 p. 4101 - 4109
反应条件
bromine in dichloromethane T=0 - 20°C; 2.08333 h;
参考文献
VALEANT PHARMACEUTICALS INTERNATIONAL
Patent: US2008/318979 A1, 2008 ;
Location in patent: Page/Page column 20 ;
US 20080318979 A1
反应条件
sodium nitrite in sulfuric acid; water; acetone
参考文献
Yale University
Patent: US5281715 A1, 1994 ;
反应条件
sulfuric acid; sodium nitrite a.) 0 deg C, 15 min, b.) reflux, 15 min;
参考文献
Wang, Yuqiang; Liu, Mao-Chin; Lin, Tai-Shun; Sartorelli, Alan C.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3667 - 3671
反应条件
sulfuric acid Diazotization.und anschliessenden Erwaermen;
参考文献
Furukawa
Yakugaku Zasshi, 1956 , vol. 76, p. 900
Chem.Abstr., 1957 , p. 2770
参考文献
Furukawa
Yakugaku Zasshi, 1956 , vol. 76, p. 900
Chem.Abstr., 1957 , p. 2770
