1: acetone With 6'-hydroxy-9-amino-9-deoxy-epiquinidine; (S)-BINOL-phosphoric acid T=20°C; 0.166667 h; 2: (E)-Ethyl 3-methyl-4-oxo-2-pentenoate; phenylmethanethiol T=40°C; sulfa Michael addition; 60 h; optical yield given as percent eestereoselective reaction;