2,5-二氯-3-甲基-吡嗪合成路线 （共 3 条）
反应条件
trichlorophosphate 60-70 deg C, 3h, then 90-100 deg C, 1h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 23, # 3 p. 871 - 875
反应条件
trichlorophosphate Heating; Yield given;
参考文献
Journal of Heterocyclic Chemistry, , vol. 23, # 3 p. 871 - 875
反应条件
1: With triethylamine in ethanol; water
T=170°C; 0.666667 h;
2: With lithium hydroxide in tetrahydrofuran; ethanol; water
T=20°C;
3: in tetrahydrofuran; ethanol; water
pH=1;
参考文献
ASTRAZENECA AB
Patent: WO2007/8146 A1, 2007 ;
Location in patent: Page/Page column 45 ;
WO 2007/008146 A1
