2,3,4,5-四氢-1H-3-苯并氮杂卓-7-胺合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in methanol 4 h;
参考文献
LECTUS THERAPEUTICS LIMITED
Patent: WO2008/38051 A2, 2008 ;
Location in patent: Page/Page column 34 ;
WO 2008/038051 A2
反应条件
1: aq. NaHCO3 / tetrahydrofuran / 20 °C 2: NH4NO3; H2SO4 3: H2 / Pd/C / ethanol 4: NaOH / methanol / Heating View Scheme
参考文献
Johnson, Paul D.; Aristoff, Paul A.; Zurenko, Gary E.; Schaadt, Ronda D.; Yagi, Betty H.; Ford, Charles W.; Hamel, Judith C.; Stapert, Douglas; Moerman, Judy K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4197 - 4200
反应条件
1: NH4NO3; H2SO4 2: H2 / Pd/C / ethanol 3: NaOH / methanol / Heating View Scheme
参考文献
Johnson, Paul D.; Aristoff, Paul A.; Zurenko, Gary E.; Schaadt, Ronda D.; Yagi, Betty H.; Ford, Charles W.; Hamel, Judith C.; Stapert, Douglas; Moerman, Judy K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4197 - 4200
反应条件
1: H2 / Pd/C / ethanol 2: NaOH / methanol / Heating View Scheme
参考文献
Johnson, Paul D.; Aristoff, Paul A.; Zurenko, Gary E.; Schaadt, Ronda D.; Yagi, Betty H.; Ford, Charles W.; Hamel, Judith C.; Stapert, Douglas; Moerman, Judy K.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 23 p. 4197 - 4200
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 2: With hydrogenchloride; copper(l) chloride in water Sandmeyer reaction;
参考文献
Shah, Unmesh; Lankin, Claire M.; Boyle, Craig D.; Chackalamannil, Samuel; Greenlee, William J.; Neustadt, Bernard R.; Cohen-Williams, Mary E.; Higgins, Guy A.; Ng, Kwokei; Varty, Geoffrey B.; Zhang, Hongtao; Lachowicz, Jean E.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4204 - 4209
反应条件
1: With hydrogen bromide; sodium nitrite in water
T=0°C;
2: With hydrogen bromide; copper(I) bromide in water
Sandmeyer reaction;
参考文献
Shah, Unmesh; Lankin, Claire M.; Boyle, Craig D.; Chackalamannil, Samuel; Greenlee, William J.; Neustadt, Bernard R.; Cohen-Williams, Mary E.; Higgins, Guy A.; Ng, Kwokei; Varty, Geoffrey B.; Zhang, Hongtao; Lachowicz, Jean E.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4204 - 4209
