2,5-二溴-1,4-二甲基苯合成路线 （共 51 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; 2-azidoethanol in toluene T=80°C; Condensation; 12 h;
参考文献
Iovine; Kellett; Redmore; Therien
Journal of the American Chemical Society, 2000 , vol. 122, # 36 p. 8717 - 8727
反应条件
tert.-butyl lithium in tetrahydrofuran T=-78°C; 1 h;
参考文献
Park, Young-Il; Lee, Joong Suk; Kim, Beom Joon; Kim, Beomjin; Lee, Jaehyun; Kim, Do Hwan; Oh, Se-Young; Cho, Jeong Ho; Park, Jong-Wook
Chemistry of Materials, 2011 , vol. 23, # 17 p. 4038 - 4044
参考文献
Jannasch
Chemische Berichte, 1877 , vol. 10, p. 1355
参考文献
Jannasch
Chemische Berichte, 1877 , vol. 10, p. 1355
反应条件
1.1: 44 percent / N-bromosuccinimide; 1,1'-azobis(cyclohexanecarbonitrile) / benzene / 8 h / Heating 2.1: triphenylphosphine / dimethylformamide / 18 h / Heating 2.2: 90 percent / potassium tert-butoxide / tetrahydrofuran 3.1: 94 percent / tetrakis(triphenylphosphine)palladium(0); sodium carbonate / 1,2-dimethoxy-ethane; ethanol; H2O / 16 h / Heating 4.1: 83 percent / bis(tricyclohexylphosphine)(benzylidene)ruthenium dichloride / CH2Cl2 / 23 h / 35 °C View Scheme
参考文献
Bonifacio, Margel C.; Robertson, Charles R.; Jung, Jun-Young; King, Benjamin T.
Journal of Organic Chemistry, 2005 , vol. 70, # 21 p. 8522 - 8526
反应条件
1: With chromium(VI) oxide; sulfuric acid; acetic anhydride in ethanol T=0 - 10°C; 2: With sulfuric acid in ethanol; water Heating; Further stages.;
参考文献
You, Wei; Wang, Liming; Wang, Qing; Yu, Luping
Macromolecules, 2002 , vol. 35, # 12 p. 4636 - 4645
反应条件
1: 1,4-dibromo-2,5-dimethylbenzene With N,N,N',N,-tetramethylethylenediamine; tert.-butyl lithium in tetrahydrofuran; pentane T=-70°C; 2.5 h; 2: carbon dioxide T=-70°C; Further stages.;
参考文献
Dyatkina, Natalia B.; Roberts, Christopher D.; Keicher, Jesse D.; Dai, Yuqin; Nadherny, Joshua P.; Zhang, Wentao; Schmitz, Uli; Kongpachith, Ana; Fung, Kevin; Novikov, Alexander A.; Lou, Lillian; Velligan, Mark; Khorlin, Alexander A.; Chen, Ming S.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 4 p. 805 - 817
反应条件
1: 81 percent / dimethylformamide / 48 h / Heating 2: KOH / bis-(2-hydroxy-ethyl) ether / Heating View Scheme
参考文献
Ngola, Sarah M.; Kearney, Patrick C.; Mecozzi, Sandro; Russell, Keith; Dougherty, Dennis A.
Journal of the American Chemical Society, 1999 , vol. 121, # 6 p. 1192 - 1201
反应条件
C24H12Cu2F9N4O7; tetrabutylammomium bromide; ammonia; caesium carbonate in water T=110 - 140°C; 16 h;
参考文献
Liao, Bei-Sih; Liu, Shiuh-Tzung
Journal of Organic Chemistry, 2012 , vol. 77, # 15 p. 6653 - 6656
反应条件
pyridine; potassium permanganate in water
参考文献
ETERNAL CHEMICAL CO., LTD.
Patent: US2010/168444 A1, 2010 ;
Location in patent: Page/Page column 4-8 ;
