3-(咪唑-4-基)丙酸合成路线 (共 18 条)
反应条件
palladium 10 on activated carbon; ammonium formate in methanol 6 h; Inert atmosphereReflux;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1693 - 1703
反应条件
hydrogenchloride; water T=100°C; 8 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 13 p. 3972 - 3976
反应条件
water; iron(III) chloride
参考文献
Chemische Berichte, , vol. 66, p. 151,158
Nippon Kagaku Kaishi, , vol. 52, p. 844,850
参考文献
B.Ph.P., , vol. 7, p. 145,147
反应条件
1: H2O; sodium-amalgam; acetic acid 2: aqueous H2O2 View Scheme
参考文献
Chemische Berichte, , vol. 66, p. 151,158
Nippon Kagaku Kaishi, , vol. 52, p. 844,850
反应条件
Bei bakterieller Zersetzung;
参考文献
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 65, p. 508
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, , vol. 154, p. 1826
反应条件
1: sulfuric acid / 12 h / Heating 2: LiAlH4 / tetrahydrofuran / 15 h / 20 °C 3: triethylamine / dimethylformamide / 2 h / 20 °C View Scheme
参考文献
Wijtmans, Maikel; De Graaf, Chris; De Kloe, Gerdien; Istyastono, Enade P.; Smit, Judith; Lim, Herman; Boonnak, Ratchanok; Nijmeijer, Saskia; Smits, Rogier A.; Jongejan, Aldo; Zuiderveld, Obbe; De Esch, Iwan J. P.; Leurs, Rob
Journal of Medicinal Chemistry, 2011 , vol. 54, # 6 p. 1693 - 1703
反应条件
sodium chloride in methanol; dichloromethane
参考文献
Bridger, Gary; Kaller, Al; Harwig, Curtis; Skerlj, Renato; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher D.; Di Fluri, Maria R.
Patent: US2004/19058 A1, 2004 ;
US 20040019058 A1
反应条件
sulfuric acid 15 h; Heating / reflux;
参考文献
Bridger, Gary; Skerlj, Renato; Kaller, Ai; Harwig, Curtis; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher Dennis; Di Fluri, Maria Rosaria
Patent: US2003/220341 A1, 2003 ;
Location in patent: Page/Page column 36-37 ;
US 20030220341 A1
反应条件
potassium carbonate in water; acetonitrile 3 h;
参考文献
SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)
Patent: EP1382607 A2, 2004 ;
Location in patent: Page 23 ;