2,4-二甲基-3-硝基吡啶合成路线 （共 11 条）
反应条件
sulfuric acid; potassium nitrate 1.) 0 deg C, 1 h, 2.) room temperature, 2 h, 3.) 100 deg C, 5 h, 4.) 130 deg C, 4h;
参考文献
Heterocycles, , vol. 28, # 2 p. 1101 - 1113
反应条件
sulfuric acid; potassium nitrate
参考文献
Vion Pharmaceuticals, Inc.
Patent: US5869676 A1, 1999 ;
参考文献
Journal fuer Praktische Chemie (Leipzig), , vol. <4> 2, p. 87,93
反应条件
sulfuric acid; benzeneseleninic anhydride; potassium nitrate 1.) 0 deg C, 1 h, room temperature, 2 h; 100 deg C, 5 h; 130 deg C, 4h, 2.) dioxane, reflux; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Heterocycles, , vol. 28, # 2 p. 1101 - 1113
反应条件
1: 5 percent / N,N-dimethylformamide / 16 h / 100 °C 2: 33 mg / H2 / 10percent Pd/C / ethanol / 4 h View Scheme
参考文献
Mahadevan,Indumathy; Rasmussen, Malcolm
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 2 p. 359 - 367
反应条件
selenium(IV) oxide in 1,4-dioxane 35 h; Heating;
参考文献
Wang, Yuqiang; Liu, Mao-Chin; Lin, Tai-Shun; Sartorelli, Alan C.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3667 - 3671
反应条件
1: 98 percent / H2 / 5percent Pd/C / ethanol / 2 h / 3102.9 Torr 2: 51 percent / aq. sulfuric acid, aq. sodium nitrite / a.) 0 deg C, 15 min, b.) reflux, 15 min View Scheme
参考文献
Furukawa
Yakugaku Zasshi, 1956 , vol. 76, p. 900
Chem.Abstr., 1957 , p. 2770
反应条件
hydrogen; palladium on activated charcoal in ethanol P=3102.9 Torr; 2 h;
参考文献
Wang, Yuqiang; Liu, Mao-Chin; Lin, Tai-Shun; Sartorelli, Alan C.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3667 - 3671
反应条件
hydrogen; palladium in ethanol
参考文献
Merck and Co., Inc.
Patent: US6610692 B1, 2003 ;
US 6610692 B1
