2-亚苄基-1,1-二甲基肼合成路线 （共 39 条）
反应条件
1: 4-(dimethylamino)picolinaldehyde N,N-dibenzylhydrazone; bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I) / tetrahydrofuran / 24 h / 80 °C / |Inert atmosphere 2: palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; potassium phosphate / N,N-dimethyl-formamide / 80 °C / |Inert atmosphere 3: MMPP / methanol / 0 h / 20 °C 4: Na2S2O5; Sodium bromate / water; ethyl acetate / 20 °C View Scheme
参考文献
Lopez-Rodriguez, Rocio; Ros, Abel; Fernandez, Rosario; Lassaletta, Jose M.
Journal of Organic Chemistry, 2012 , vol. 77, # 21 p. 9915 - 9920
反应条件
1: 4-(dimethylamino)picolinaldehyde N,N-dibenzylhydrazone; bis(η4-1,5-cyclooctadiene)-di-μ-methoxy-diiridium(I) / tetrahydrofuran / 24 h / 80 °C / |Inert atmosphere 2: palladium(II) dichloride bis[bis(diphenylphosphine)ferrocene]; potassium phosphate / N,N-dimethyl-formamide / 80 °C / |Inert atmosphere 3: MMPP / methanol / 0 h / 20 °C View Scheme
参考文献
Lopez-Rodriguez, Rocio; Ros, Abel; Fernandez, Rosario; Lassaletta, Jose M.
Journal of Organic Chemistry, 2012 , vol. 77, # 21 p. 9915 - 9920
反应条件
1: 76 percent / pyridine / 5 h / 20 °C
2: 13 percent / aq. HCl / acetonitrile / 24 h / 20 °C
View Scheme
参考文献
Kamitori, Yasuhiro; Hojo, Masaru; Masuda, Ryoichi; Ohara, Seiji; Kawamura, Yoshihiko; Ebisu, Toshiaki
Synthesis, 1989 , # 1 p. 43 - 45
反应条件
1.1: cesium fluoride / acetonitrile / 10 h / 65 °C
2.1: hydrogenchloride; water / acetonitrile / 2 h / 65 °C
3.1: cesium fluoride / acetonitrile / 10 h / 65 °C
3.2: 2 h / 65 °C
View Scheme
参考文献
Dubrovskiy, Anton V.; Larock, Richard C.
Journal of Organic Chemistry, 2012 , vol. 77, # 24 p. 11232 - 11256
反应条件
1: With acetic anhydride; cesium fluoride in acetonitrile
T=65°C; 10 h;
2: With hydrazine hydrate in water
T=100°C; 10 h;
参考文献
Markina, Nataliya A.; Dubrovskiy, Anton V.; Larock, Richard C.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 12 p. 2409 - 2412
反应条件
1.1: cesium fluoride / acetonitrile / 10 h / 65 °C
2.1: N-chloro-succinimide / acetonitrile / 2 h / 65 °C
2.2: 10 h / 130 °C
View Scheme
参考文献
Dubrovskiy, Anton V.; Larock, Richard C.
Journal of Organic Chemistry, 2012 , vol. 77, # 24 p. 11232 - 11256
反应条件
1: cesium fluoride / acetonitrile / 10 h / 65 °C
2: N-chloro-succinimide; potassium carbonate / acetonitrile / 65 °C
View Scheme
参考文献
Dubrovskiy, Anton V.; Larock, Richard C.
Journal of Organic Chemistry, 2012 , vol. 77, # 24 p. 11232 - 11256
反应条件
dihydrogen peroxide; methyltrioxorhenium (VII) in ethanol
T=-50 - 20°C; 1 h;
参考文献
Rudler, Henri; Denise, Bernard
Chemical Communications, 1998 , # 19 p. 2145 - 2146
反应条件
hydrazine in ethanol
3 h; Heating;
参考文献
Werbel; Hung; McNamara; Ortwine
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 4 p. 363 - 370
