1-(3,5-二氟吡啶-2-基)乙酮合成路线 （共 2 条）
反应条件
1: in tetrahydrofuran T=-78 - -4°C; 2: With hydrogenchloride; water in tetrahydrofuran T=0 - 20°C; 1 h; 3: With sodium hydrogencarbonate in water pH=9;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/150462 A1, 2009 ;
Location in patent: Page/Page column 80-81 ;
WO 2009/150462 A1
反应条件
sodium tetrahydroborate in methanol T=-10°C; 0.5 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2008/132502 A1, 2008 ;
Location in patent: Page/Page column 98 ;
WO 2008/132502 A1
