2,3-二氨基苯甲酸甲酯合成路线 （共 23 条）
反应条件
hydrogen; 20 Pd(OH)2 on carbon in ethanol T=20°C; P=3040.2 Torr; 48 h;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; DISCH, Jeremy, S.; NG, Pui, Yee; BLUM, Charles, A.; PERNI, Robert, B.
Patent: WO2010/3048 A1, 2010 ;
Location in patent: Page/Page column 117 ;
WO 2010/003048 A1
反应条件
1: With trifluoroacetic acid T=20°C; 3 h; 2: With sodium hydrogencarbonate in water Product distribution / selectivity;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: US2009/186879 A1, 2009 ;
Location in patent: Page/Page column 50 ;
US 20090186879 A1
反应条件
1: diethyl ether / 0 °C 2: 96 percent / hydrogen / Pd/C / methanol / 3 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 17 p. 6106 - 6119
反应条件
palladium in ethanol
参考文献
Ferraris, Dana V.; Li, Jia-He; Kalish, Vincent J.; Zhang, Jie
Patent: US2003/22883 A1, 2003 ;
反应条件
thionyl chloride T=0 - 80°C; 4 h;
参考文献
Bulletin of the Korean Chemical Society, , vol. 34, # 8 p. 2297 - 2304
反应条件
1: sodium methoxide / methanol / 20 °C 2: 96 percent / hydrogen / Pd/C / methanol / 3 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 17 p. 6106 - 6119
反应条件
1: acetic anhydride; acetic acid; nitric acid / 2.5 h / 5 - 15 °C 2: sodium methoxide / methanol / 20 °C 3: 96 percent / hydrogen / Pd/C / methanol / 3 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 14, # 17 p. 6106 - 6119
反应条件
1: 93 percent / Br2; aq. KOH / 3 h / 60 °C 2: 60 percent / HCl(g) / 6 h / Heating 3: 94 percent / H2 / 10percent Pd/C / methanol / 760.05 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 22 p. 4084 - 4097
反应条件
1: sulfuric acid / 2.5 h / 90 °C / |Inert atmosphere 2: sodium hydroxide; dihydrogen peroxide / water / 0 - 20 °C / |Inert atmosphere 3: hydrogenchloride / water / 12 h / |Reflux; |Inert atmosphere 4: palladium 10 on activated carbon; hydrogen / methanol / 8 h / |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 78, # 17 p. 8217 - 8231
