5-甲氧基-2-甲基吲哚合成路线 （共 49 条）
反应条件
1: 85 percent / 2-methyl-propan-2-ol / 0.5 h / Heating 2: 96 percent / thiosalicylic acid / trifluoroacetic acid / 1.5 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 59, # 21 p. 6372 - 6377
反应条件
1: toluene / 1.) 6 h, RT; 2.) 3 h, 100 deg C 2: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating 3: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 4: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 41, # 22 p. 5313 - 5320
反应条件
1: N-bromosuccinimide (NBS), azoisobutyronitrile (AIBN) / CCl4 / 3 h / Heating 2: toluene / 1.) 6 h, RT; 2.) 3 h, 100 deg C 3: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating 4: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 5: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 41, # 22 p. 5313 - 5320
反应条件
1: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 2: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 41, # 22 p. 5313 - 5320
反应条件
1: 74 percent / 48percent HBr, Zn / ethanol / 2 h / Heating 2: 92 percent / pyridine / CH2Cl2 / 1 h / Heating 3: 97 percent / t-BuOK / toluene / 0.25 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 41, # 22 p. 5313 - 5320
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in 1,4-dioxane Suzuki coupling; Reflux;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 8 p. 2586 - 2590
参考文献
Zhurnal Obshchei Khimii, , vol. 26, p. 1449,1450; engl. Ausg. S. 1629
反应条件
1: sulfuric acid; acetic acid / 30 - 70 °C / Large scale reaction 2: methanol / 30 - 35 °C / Large scale reaction 3: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction View Scheme
参考文献
Research on Chemical Intermediates, , vol. 36, # 8 p. 975 - 983
反应条件
1: methanol / 30 - 35 °C / Large scale reaction 2: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction View Scheme
参考文献
Research on Chemical Intermediates, , vol. 36, # 8 p. 975 - 983
反应条件
1.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Large scale reaction 1.2: 20 °C / Large scale reaction 1.3: 10 °C / pH 4 - 5 / Large scale reaction 2.1: sulfuric acid; acetic acid / 30 - 70 °C / Large scale reaction 3.1: methanol / 30 - 35 °C / Large scale reaction 4.1: sodium dithionite / tetrahydrofuran; water / 20 °C / Large scale reaction View Scheme
参考文献
Research on Chemical Intermediates, , vol. 36, # 8 p. 975 - 983
