5-甲氧基-2-甲基吲哚合成路线 （共 49 条）
反应条件
potassium hydroxide in tetrahydrofuran; ethanol Reflux;
参考文献
Tetrahedron Letters, , vol. 55, # 11 p. 1859 - 1862
反应条件
sodium hydroxide; ethanol; water
参考文献
Journal of the Chemical Society, , p. 2029,2031
反应条件
2,2,6,6-tetramethylpiperidinyl-lithium 1) -10 degC, THF, 2) 0 degC, 20 min; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 46, # 4 p. 1379 - 1384
参考文献
Chemische Berichte, , vol. 58, p. 520
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / 0 - 20 °C 1.2: 0.5 h 1.3: 24 h 2.1: potassium tert-butylate / tetrahydrofuran / 1 h / -78 °C 2.2: 3 h 3.1: lithium hydroxide hydrate / water / 6 h / 25 °C View Scheme
参考文献
Gong, Tian-Jun; Cheng, Wan-Min; Su, Wei; Xiao, Bin; Fu, Yao
Tetrahedron Letters, 2014 , vol. 55, # 11 p. 1859 - 1862
反应条件
1: 99 percent / silica gel; N-bromosuccinimide / CH2Cl2 / 0.5 h / 20 °C 2: 94 percent / sodium hydride / tetrahydrofuran; various solvent(s) / 18 h / 20 °C View Scheme
参考文献
De Koning, Charles B.; Michael, Joseph P.; Nhlapo, Johanna M.; Pathak, Rakhi; Van Otterlo, Willem A. L.
Synlett, 2003 , # 5 p. 705 - 707
反应条件
1: 58 percent / trifluoroacetic acid / 0.5 h / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
Ismaiel; Titeler; Miller; Smith; Glennon
Journal of medicinal chemistry, 1990 , vol. 33, # 2 p. 755 - 758
反应条件
boron tribromide in dichloromethane T=0 - 20°C; 2 h;
参考文献
Mattsson, Cecilia; Svensson, Peder; Boettcher, Henning; Sonesson, Clas
European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 578 - 588
反应条件
1: 1.) MeMgCl, ZnCl2 / 1.) Et2O 2: 1.) KHMDS, HMPA / 1.) THF View Scheme
参考文献
Gallant, Michel; Dufresne, Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petpiboon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Metters, Kathleen M.; Labelle, Marc
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 19 p. 2263 - 2268
反应条件
sodium hydroxide in N,N-dimethyl-formamide T=20°C; 0.833333 h;
参考文献
Xu, Cong; Liu, Jingxin; Ming, Wenbo; Liu, Yingjie; Liu, Jun; Wang, Mang; Liu, Qun
Chemistry - A European Journal, 2013 , vol. 19, # 28 p. 9104 - 9109
