potassium tert-butylate in tetrahydrofuran T=-15°C; 2 h;

1: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 2: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 3: m-CPB 4: 11 percent / t-BuOK / tetrahydrofuran / 2 h / -15 °C View Scheme

1: acetic anhydride / 0.25 h / Ambient temperature 2: 10percent aq. NaOH, 30percent aq. H2O2 / acetone / 0.5 h / Ambient temperature 3: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 4: m-CPB 5: 11 percent / t-BuOK / tetrahydrofuran / 2 h / -15 °C View Scheme

1: 1.) NaH / 1.) DMF, RT, 5 min, 2.) DMF, 50 deg C, 17 h 2: m-CPB 3: 11 percent / t-BuOK / tetrahydrofuran / 2 h / -15 °C View Scheme

1: m-CPB 2: 11 percent / t-BuOK / tetrahydrofuran / 2 h / -15 °C View Scheme