1: 2-iodopyrazine With (nBu)3MgLi in tetrahydrofuran; hexane T=-10°C; 2.5 h; 2: diphenyldisulfane in tetrahydrofuran; hexane T=-10 - 20°C; 19 h;

1: 2-chloro-pyrazine With palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: In(SPh)3 With N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=100°C; 2 h; Inert atmosphere;

in 1-methyl-pyrrolidin-2-one T=80°C; 0.00972222 h; microwave irradiation;

sodium hydride in dimethyl sulfoxide 5 h; Heating;

tetrakis(triphenylphosphine) palladium(0); Cu(I) 3-methylsalicylate in tetrahydrofuran T=50°C; 42 h;