5-碘-1H-吲哚唑-3-甲酸合成路线 (共 4 条)
反应条件
1: With methanol; sodium hydroxide; water in tetrahydrofuran T=75°C; 4 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=1;
参考文献
Ube Industries, Ltd.; SANTEN PHARMACEUTICAL CO., LTD.
Patent: EP1679308 A1, 2006 ;
Location in patent: Page/Page column 39 ;
EP 1679308 A1
反应条件
1: With sodium hydroxide in water Heating / reflux; 2: With sulfuric acid; sodium nitrite in water T=0 - 4°C; 0.25 h; 3: With hydrogenchloride; tin(ll) chloride in water T=4°C;
参考文献
US2006/4000 A1, ;
Page/Page column 12-13 ;
反应条件
1: With sodium nitrite in sulfuric acid T=0°C; 1.25 h; 2: With potassium iodide in sulfuric acid pH=3 - 4; 24 h; Further stages.;
参考文献
Schmidt, Andreas; Snovydovych, Bohdan; Habeck, Tobias; Droettboom, Petra; Gjikaj, Mimoza; Adam, Arnold
European Journal of Organic Chemistry, 2007 , # 29 p. 4909 - 4916
反应条件
sulfuric acid 6 h; Heating;
参考文献
European Journal of Organic Chemistry, , # 29 p. 4909 - 4916