1: 1.) NaH / 1.) DMF, 50 deg C, 15 min; 2) DMF, 80 deg C, 5 h 2: 10 N HCl / methanol / 3 h / Ambient temperature 3: 72 percent / Al-Hg / tetrahydrofuran; H2O / 5 h 4: t-BuOK / tetrahydrofuran / 1 h / 60 °C View Scheme

Multi-step reaction with 2 steps 1: 1.) NaH / 1.) DMF, 50 deg C, 15 min; 2) DMF, 80 deg C, 5 h2: 10 N HCl / methanol / 3 h / Ambient temperature  

Multi-step reaction with 2 steps 1: 95 percent / Al-Hg / tetrahydrofuran; H2O / 5 h2: 1.) n-BuLi / 1.) THF, -65 deg C to 20 deg C, 0.5 h; 2) -30 deg C, 15 h  

Multi-step reaction with 3 steps 1: 1.) NaH / 1.) DMF, 50 deg C, 15 min; 2) DMF, 80 deg C, 5 h2: 10 N HCl / methanol / 3 h / Ambient temperature3: 72 percent / Al-Hg / tetrahydrofuran; H2O / 5 h